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Article

Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6

1 Jan 2012

Abstract excerpt

Low density lipoprotein receptor (LDLR) plays an important role in the cholesterol homeostasis. We examined the possible circadian regulation of LDLR and mechanism(s) underlying it. In mice, blood glucose and plasma triglyceride, total and high density lipoprotein cholesterol varied distinctively throughout a day. In addition, LDLR mRNA oscillated in the liver in a functional clock-dependent manner. Accordingly,...

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Share to Cholesterol and Lipid Metabolism
Share to Circadian rhythm and melatonin
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PMID: 22913986
DOI: 10.3858/emm.2012.44.11.073

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