Human genetic variation determines 24-hour rhythmic gene expression and disease risk

Abstract excerpt

<title>Abstract</title> <p>24-hour biological rhythms are essential to maintain physiological homeostasis. Disruption of these rhythms increases the risks of multiple diseases. The biological rhythms are known to have a genetic basis formed by core clock genes, but how individual genetic variation shapes the oscillating transcriptome and contributes to human chronophysiology and disease risk is largely unknown. H...

Topics

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• Circadian Clocks
• Circadian Rhythm
• Circadian rhythm and melatonin
• CLOCK Proteins
• Gene Expression Regulation
• Genome-Wide Association Study
• Organ Specificity
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

64643f11-5de0-540d-b6fd-c9c848d3e5ea

DOI

10.21203/rs.3.rs-4790200/v1