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Article

Hypercholesterolemia Causes Circadian Dysfunction: A Potential Risk Factor for Cardiovascular Disease.

EBioMedicine - 1 Jun 2017

Akashi Makoto, Matsumura Ritsuko, Matsuo Takahiro, Kubo Yuki, Komoda Hiroshi, Node Koichi

Abstract excerpt

Hypercholesterolemia is a well-known risk factor for a wide range of diseases in developed countries. Here, we report that mice lacking functional LDLR (low density lipoprotein receptor), an animal model of human familial hypercholesterolemia, show circadian abnormalities. In free running behavioral experiments in constant darkness, these mice showed a prolonged active phase and distinctly bimodal rhythms. Even...

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Source

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Identifiers

PMID: 28499924
DOI: 10.1016/j.ebiom.2017.04.034
PMCID: PMC5478205

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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