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Article

Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors.

PloS one - 1 Jan 2012

Braun Kathleen R, DeWispelaere Allison M, Bressler Steven L, Fukai Nozomi, Kenagy Richard D, Chen Lihua, Clowes Alexander W, Kinsella Michael G

Abstract excerpt

Syndecans are receptors for soluble ligands, including heparin-binding growth factors, and matrix proteins. However, intracellular targets of syndecan-1 (Sdc-1)-mediated signaling are not fully understood. A yeast two-hybrid protein interaction screening of a mouse embryo library identified the ubiquitin and SUMO-1 E3 ligase, Topors, as a novel ligand of the Sdc-1 cytoplasmic domain (S1CD), a finding confirmed by...

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Identifiers

PMID: 22912899
DOI: 10.1371/journal.pone.0043701
PMCID: PMC3422340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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