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Article

TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.

PloS one - 1 Jan 2016

Czub Barbara, Shah Amna Z, Alfano Giovanna, Kruczek Przemysław M, Chakarova Christina F, Bhattacharya Shomi S

Abstract excerpt

The significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of neurodegenerative diseases, including retinal dystrophies. TOPORS, a dual E3 ubiquitin and SUMO1 ligase, forms a component of the UPS and selected substrates for its enzymatic activities, such as DJ-1/PARK7 and APOBEC2, are important for neuronal as well as retinal homeostasis, respectively....

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Source

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Identifiers

PMID: 26872363
DOI: 10.1371/journal.pone.0148678
PMCID: PMC4752349

Genes

TOPORS
PSMC1
RPE
APOBEC2
PARK7
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.PMID 26872363Read ↗

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From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in DiseaseSemantic proximity Read ↗

Mutations of TOPORS identified in families with retinitis pigmentosa.Semantic proximity Read ↗

Autosomal Dominant Retinitis Pigmentosa-Associated TOPORS Protein Truncating Variants Are Exclusively Located in the Region of Amino Acid Residues 807 to 867.Semantic proximity Read ↗

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