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Article

Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules

15 May 1995

Abstract excerpt

Many human leukemias are characterized by chromosomal translocations yielding hybrid RNAs capable of encoding fusion chimeric proteins. The unique amino acid sequences found in these oncogenic fusion proteins represent true tumor-specific antigens that are potentially immunogenic. Although these leukemia-specific fusion proteins have an intracellular location, they might be recognized immunologically by T...

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Identifiers

PMID: 7742526
DOI: 10.1182/blood.v85.10.2680.bloodjournal85102680

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