Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells

21 Nov 2006

Abstract excerpt

The FLT3 receptor tyrosine kinase is expressed in more than 90% of acute myelogeneous leukemias (AMLs), up to 30% of which carry an internal tandem duplication (ITD) within the FLT3 gene. Although varying duplication sites exist, most FLT3-ITDs affect a single protein domain. We analyzed the FLT3-ITD of an AML patient for encoding HLA class I-restricted immunogenic peptides. One of the tested peptides...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to CAR-T cell therapy research
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17119119
DOI: 10.1182/blood-2006-07-032839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cellsPMID 17119119Read ↗

Flt3-ITD mutations can generate leukaemia specific neoepitopes: potential role for immunotherapeutic approaches.Semantic proximity Read ↗

Mutated <i>BCR-ABL</i> Generates Immunogenic T-cell Epitopes in CML PatientsSemantic proximity Read ↗

Identification of specific T-cell response and T-cell receptor targeting shared neoantigen for acute myeloid leukemia.Semantic proximity Read ↗

CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia.Semantic proximity Read ↗

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Semantic proximity Read ↗

Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.Semantic proximity Read ↗

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.Semantic proximity Read ↗

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.Semantic proximity Read ↗

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo.Semantic proximity Read ↗

Specific binding of leukemia oncogene fusion protein peptides to HLA class I moleculesSemantic proximity Read ↗

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AMLSemantic proximity Read ↗

Specific pattern of protein expression in acute myeloid leukemia harboring FLT3-ITD mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.