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Sessile Serrated Polyps and Colon Cancer Prevention

22 Mar 2017

Abstract excerpt

Abstract Evidence suggests that up to one fifth of colorectal carcinomas develop from serrated polyps, named for their pattern of colonic crypts, and include the sessile serrated adenoma/polyp (SSA/P) that has malignant potential. SSA/Ps are typically located in the proximal colon and have molecular features of hypermethylation of CpG islands in gene promoters and activating point mutations (V600E) in the BRAF...

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PMID: 28325827
DOI: 10.1158/1940-6207.capr-16-0264

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