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Article

Whole Transcriptome Analysis of the Effects of Type I Diabetes on Mouse Oocytes

24 Jul 2012

Abstract excerpt

In mouse ovarian follicles, granulosa cells but not oocytes take up glucose to provide the oocyte with nourishments for energy metabolism. Diabetes-induced hyperglycemia or glucose absorption inefficiency consistently causes granulosa cell apoptosis and further exerts a series of negative impacts on oocytes including reduced meiosis resumption rate, low oocyte quality and preimplantation embryo degeneration. Here...

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PMID: 22911868
DOI: 10.1371/journal.pone.0041981

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