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Gestational diabetes mellitus causes genome hyper-methylation of oocyte via increased EZH2

2 Jan 2025

Abstract excerpt

Gestational diabetes mellitus (GDM), a common pregnancy disease, has long-term negative effects on offspring health. Epigenetic changes may have important contributions to that, but the underlying mechanisms are not well understood. Here, we report the influence of GDM on DNA methylation of offspring (GDF1) oocytes and the possible mechanisms. Our results show that GDM induces genomic hyper-methylation of...

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PMID: 39747080
DOI: 10.1038/s41467-024-55499-x

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