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Article

Maternal Diabetes Causes Mitochondrial Dysfunction and Meiotic Defects in Murine Oocytes

3 Jul 2009

Abstract excerpt

The adverse effects of maternal diabetes on embryo development and pregnancy outcomes have recently been shown to occur as early as the one-cell zygote stage. The hypothesis of this study was that maternally inherited mitochondria in oocytes from diabetic mice are abnormal and thus responsible in part for this latency of developmental compromise. In ovulated oocytes from diabetic mice, transmission electron...

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Identifiers

PMID: 19574447
DOI: 10.1210/me.2009-0033

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