Article
Inherited Inflammatory Response Genes Are Associated with B-Cell Non-Hodgkin's Lymphoma Risk and Survival.
PloS one - 1 Jan 2015
Nielsen Kaspar René, Steffensen Rudi, Bendtsen Mette Dahl, Rodrigo-Domingo Maria, Baech John, Haunstrup Thure Mors, Bergkvist Kim Steve, Schmitz Alexander, Boedker Julie Stoeveve, Johansen Preben, Dybkaeær Karen, Boeøgsted Martin, Johnsen Hans Erik
Abstract excerpt
BACKGROUND: Malignant B-cell clones are affected by both acquired genetic alterations and by inherited genetic variations changing the inflammatory tumour microenvironment. METHODS: We investigated 50 inflammatory response gene polymorphisms in 355 B-cell non-Hodgkin's lymphoma (B-NHL) samples encompassing 216 diffuse large B cell lymphoma (DLBCL) and 139 follicular lymphoma (FL) and 307 controls. The effect of...
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