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Article

Novel nucleoside analogue FNC is effective against both wild-type and lamivudine-resistant HBV clinical isolates.

Antiviral therapy - 1 Jan 2012

Zhou Yubing, Zhang Yan, Yang Xiaoang, Zhao Jing, Zheng Liyun, Sun Changyu, Jiang Jinhua, Yang Qinghua, Wang Qingduan, Chang Junbiao

Abstract excerpt

BACKGROUND: HBV infection causes major public health problems worldwide. The clinical limitation of current antiviral drugs for HBV, such as lamivudine, is causing rapid emergence of drug-resistant viral strains during prolonged antiviral therapy. Therefore, new antiviral drugs are urgently needed to prevent or delay the selection of drug-resistant HBV mutants. A novel cytidine analogue, FNC...

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Identifiers

PMID: 22910281
DOI: 10.3851/IMP2292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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