Article
Androgen receptor function links human sexual dimorphism to DNA methylation.
PloS one - 1 Jan 2013
Ammerpohl Ole, Bens Susanne, Appari Mahesh, Werner Ralf, Korn Bernhard, Drop Stenvert L S, Verheijen Frans, van der Zwan Yvonne, Bunch Trevor, Hughes Ieuan, Cools Martine, Riepe Felix G, Hiort Olaf, Siebert Reiner, Holterhus Paul-Martin
Abstract excerpt
Sex differences are well known to be determinants of development, health and disease. Epigenetic mechanisms are also known to differ between men and women through X-inactivation in females. We hypothesized that epigenetic sex differences may also result from sex hormone functions, in particular from long-lasting androgen programming. We aimed at investigating whether inactivation of the androgen receptor, the key...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.