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Article

Phenotype of transgenic mice overexpressed with inducible nitric oxide synthase in the retina.

PloS one - 1 Jan 2012

Wu Guey Shuang, Jiang Meisheng, Liu Yi-Hsin, Nagaoka Yoshiko, Rao Narsing A

Abstract excerpt

BACKGROUND: Unlike its constitutive isoforms, including neuronal and endothelial nitric oxide synthase, inducible nitric oxide synthase (iNOS) along with a series of cytokines are generated in inflammatory pathologic conditions in retinal photoreceptors. In this study, we constructed transgenic mice overexpressing iNOS in the retina to evaluate the effect of sustained, intense iNOS generation in the photoreceptor...

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Identifiers

PMID: 22905206
DOI: 10.1371/journal.pone.0043089
PMCID: PMC3414486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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