Article
Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2009
Usui Shinichi, Komeima Keiichi, Lee Sun Young, Jo Young-Joon, Ueno Shinji, Rogers Brian S, Wu Zhihao, Shen Jikui, Lu Lili, Oveson Brian C, Rabinovitch Peter S, Campochiaro Peter A
Abstract excerpt
Oxidative and nitrosative damage are major contributors to cone cell death in retinitis pigmentosa (RP). In this study, we explored the effects of augmenting components of the endogenous antioxidant defense system in models of RP, rd1, and rd10 mice. Unexpectedly, overexpression of superoxide dismutase 1 (SOD1) in rd1 mice increased oxidative damage and accelerated cone cell death. With an elaborate mating...
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