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Article

Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis.

PloS one - 1 Jan 2012

Park Jin Kyun, Askin Frederic, Giles Jon T, Halushka Marc K, Rosen Antony, Levine Stuart M

Abstract excerpt

BACKGROUND: Tissue-infiltrating multinucleated giant cells (MNGs) within geographic necrosis are pathologic hallmarks of granulomatosis with polyangiitis (GPA). However, the origin, phenotype, and function of these cells in GPA remain undefined. METHODOLOGY/PRINCIPAL FINDINGS: MNG phenotype in GPA lung tissue was examined by immunohistochemistry using antibody directed against cathepsin K and calcitonin-receptor....

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Identifiers

PMID: 22905158
DOI: 10.1371/journal.pone.0042659
PMCID: PMC3414441

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Source receipt: pubmed, retrieved 7 Sept 2026.

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