Osteoclast-like multinucleated giant cells in sinonasal inflammation of granulomatosis with polyangiitis (Wegener's granulomatosis).

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Article

Osteoclast-like multinucleated giant cells in sinonasal inflammation of granulomatosis with polyangiitis (Wegener's granulomatosis).

Clinical and experimental rheumatology - 1 Jan 2000

Park J K, Askin F

Abstract excerpt

OBJECTIVES: To determine whether generation of osteoclast-like multinucleated giant cells (MNG) is a general feature of granulomatosis with polyangiitis (GPA). METHODS: MNG phenotype of GPA sinus was examined by immunohistochemistry using antibodies against CD68, and cathepsin K. Tartrate resistant acid phosphatase (TRAP) expression was assessed by enzymatic color reaction. Effects of bacterial wall components...

Topics

Acid Phosphatase
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Biomarkers
Cathepsin K
Cells, Cultured
Dose-Response Relationship, Drug
Giant Cells
Granulomatosis with Polyangiitis
Humans
Immunohistochemistry
Isoenzymes
Lipopolysaccharides
Lung
Osteoclasts
Paranasal Sinuses
Peptidoglycan
Phenotype

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Open in PubMed

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PMID: 23465045

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