Article
Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis.
The Journal of experimental medicine - 7 Mar 2005
da Costa Cristiana E T, Annels Nicola E, Faaij Claudia M J M, Forsyth Ramses G, Hogendoorn Pancras C W, Egeler R Maarten
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a disease that can involve one or multiple organ systems characterized by an accumulation of CD1a(+) Langerhans-like cells as well as several other myeloid cell types. The precise origin and role of one of these populations, the multinucleated giant cell (MGC), in this disease remains unknown. This work shows that in three different lesional tissues, bone, skin, and lymph...
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