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Article

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.

The Journal of cell biology - 5 Jul 2004

Edgar Julia M, McLaughlin Mark, Yool Donald, Zhang Su-Chun, Fowler Jill H, Montague Paul, Barrie Jennifer A, McCulloch Mailis C, Duncan Ian D, Garbern James, Nave Klaus A, Griffiths Ian R

Abstract excerpt

Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show that fast axonal transport is also dependent on the oligodendrocyte. Using a mouse model of hereditary spastic paraplegia type 2 due to a null mutation of the myelin Plp gene, we find a progressive impairment in fast retrograde and anterograde transport. Increased levels of retrograde...

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Identifiers

PMID: 15226307
DOI: 10.1083/jcb.200312012
PMCID: PMC2172145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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