Article
Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2012
Ding David, Scott Nicole M, Thompson Emma E, Chaiworapongsa Tinnakorn, Torres Raul, Billstrand Christine, Murray Kathleen, Dexheimer Phillip J, Ismail Mahmoud, Kay Helen, Levy Shawn, Romero Roberto, Lindheimer Marshall D, Nicolae Dan L, Ober Carole
Abstract excerpt
Preeclampsia occurs more frequently in women of African ancestry. The cause of this hypertensive complication is unclear, but placental oxidative stress may play a role. Because mitochondria are the major sites of oxidative phosphorylation, we hypothesized that placentas of preeclamptic pregnancies harbor mitochondrial DNA (mtDNA) mutations. Next-generation sequencing of placental mtDNA in African American...
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