Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia.

doi:10.1161/HYPERTENSIONAHA.123.21748

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Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2024

O'Brien Katie A, Gu Wanjun, Houck Julie A, Holzner Lorenz M W, Yung Hong Wa, Armstrong Jenna L, Sowton Alice P, Baxter Ruby, Darwin Paula M, Toledo-Jaldin Lilian, Lazo-Vega Litzi, Moreno-Aramayo Any Elena, Miranda-Garrido Valquiria, Shortt Jonathan A, Matarazzo Christopher J, Yasini Hussna, Burton Graham J, Moore Lorna G, Simonson Tatum S, Murray Andrew J, Julian Colleen G

Abstract excerpt

BACKGROUND: The chronic hypoxia of high-altitude residence poses challenges for tissue oxygen supply and metabolism. Exposure to high altitude during pregnancy increases the incidence of hypertensive disorders of pregnancy and fetal growth restriction and alters placental metabolism. High-altitude ancestry protects against altitude-associated fetal growth restriction, indicating hypoxia tolerance that is genetic...

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PMID: 38018457
DOI: 10.1161/HYPERTENSIONAHA.123.21748
PMCID: PMC10841680

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CPT2
PTPRD
TBX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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