Article
The Val66Met polymorphism of the BDNF gene influences trigeminal pain-related evoked responses.
The journal of pain - 1 Sept 2012
Di Lorenzo Cherubino, Di Lorenzo Giorgio, Daverio Andrea, Pasqualetti Patrizio, Coppola Gianluca, Giannoudas Ioannis, Barone Ylenia, Grieco Gaetano S, Niolu Cinzia, Pascale Esterina, Santorelli Filippo M, Nicoletti Ferdinando, Pierelli Francesco, Siracusano Alberto, Seri Stefano
Abstract excerpt
UNLABELLED: Cortical pain processing is associated with large-scale changes in neuronal connectivity, resulting from neural plasticity phenomena of which brain-derived neurotrophic factor (BDNF) is a central driver. The common single nucleotide polymorphism Val66Met is associated with reduced BDNF activity. Using the trigeminal pain-related evoked potential (tPREP) to repeated electrical painful stimuli, we...
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