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Article

Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex.

Gastroenterology - 1 Sept 2011

Jayasekeran Vanoo, Pendleton Neil, Holland Glenn, Payton Antony, Jefferson Samantha, Michou Emilia, Vasant Dipesh, Ollier Bill, Horan Mike, Rothwell John, Hamdy Shaheen

Abstract excerpt

BACKGROUND & AIMS: Polymorphisms in brain-derived neurotrophic factor (BDNF) can affect brain and behavioral responses. However, little is known about the effects of a single nucleotide polymorphism (SNP) in BDNF, at codon 66 (the Val-Met substitution, detected in approximately 33% of the Caucasian population) on stimulation-induced plasticity in the cortico-bulbar system. We examined whether this SNP influenced...

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Identifiers

PMID: 21699787
DOI: 10.1053/j.gastro.2011.05.047

Genes

BDNF

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