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Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells through Inhibition of Human Endogenous Retrovirus Type K

2022-02-18

Abstract excerpt

Increasing evidence points to the role of endogenous retroviruses (ERVs) in driving cancer cell proliferation. The purpose of this study was to explore the possibility of repurposing antiretroviral agents to inhibit ERVs as a new approach in cancer treatment. We found that an integrase strand-transfer inhibitor, dolutegravir (DTG), effectively inhibited the proliferation of multiple cancer cell lines and its antip...

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Identifiers and source

Literature Corpus work
ba055688-deab-5b18-9963-434e586ad94d
DOI
10.20944/preprints202202.0223.v1
Open publication

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