Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synergistic anti-tumor effects of nitroreductase mutants and p53.

Journal of cancer research and therapeutics - 1 Jan 2000

Razmkhah Mahboobeh, Habibagahi Mojtaba, Alizadeh Fatemeh, Hosseini Ahmad, Ghaderi Abbas, Searle Peter F, Jaberipour Mansooreh

Abstract excerpt

INTRODUCTION: The p53 gene therapy showed promising results for treatment of numerous cancers particularly in combination with chemotherapy or radiotherapy. Gene therapy combining two or more treatment options may lead to the synergistic effects between diverse therapies and provide many opportunities in our fight against cancer. AIM: This study focused on the effects of p53 combining with the suicide gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Cytopathogenic Effect, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Genetic Vectors

Share to Inhibitory Concentration 50

Share to Neoplasms

Share to Nitroreductases

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 25313757
DOI: 10.4103/0973-1482.139155

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergistic anti-tumor effects of nitroreductase mutants and p53.PMID 25313757Read ↗

Key points of basic theories and clinical practice in rAd-p53 (Gendicine™) gene therapy for solid malignant tumorsSemantic proximity Read ↗

Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.Semantic proximity Read ↗

Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cellsSemantic proximity Read ↗

Applications of Recombinant Adenovirus-p53 Gene Therapy for Cancers in the Clinic in China.Semantic proximity Read ↗

Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas.Semantic proximity Read ↗

Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo.Semantic proximity Read ↗

Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine.Semantic proximity Read ↗

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 InhibitorsSemantic proximity Read ↗

An in vitro model to optimize dose scheduling of multimodal radioimmunotherapy and chemotherapy: effects of p53 expression.Semantic proximity Read ↗

Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cellsSemantic proximity Read ↗

Cooperative effect of adenoviral p53 gene therapy and standard chemotherapy in ovarian cancer cells independent of the endogenous p53 status.Semantic proximity Read ↗

Involvement of p53 in gemcitabine mediated cytotoxicity and radiosensitivity in breast cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.