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Article

O-antigen modulates infection-induced pain states.

PloS one - 1 Jan 2012

Rudick Charles N, Jiang Mingchen, Yaggie Ryan E, Pavlov Vladimir I, Done Joseph, Heckman Charles J, Whitfield Christopher, Schaeffer Anthony J, Klumpp David J

Abstract excerpt

The molecular initiators of infection-associated pain are not understood. We recently found that uropathogenic E. coli (UPEC) elicited acute pelvic pain in murine urinary tract infection (UTI). UTI pain was due to E. coli lipopolysaccharide (LPS) and its receptor, TLR4, but pain was not correlated with inflammation. LPS is known to drive inflammation by interactions between the acylated lipid A component and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22899994
DOI: 10.1371/journal.pone.0041273
PMCID: PMC3416823

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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