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SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway

16 Jun 2025

Abstract excerpt

Somatosensory disorders, especially pain, are prominent symptoms of COVID-19. Except for the viral infection process, SARS-CoV-2 viral proteins might be directly sensed by corresponding receptors, thereby triggering nociceptive signals in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH). Behavioral assays were performed to screen out the nociceptive effects of the SARS-CoV-2 envelope protein (S2E) and...

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PMID: 40589538
DOI: 10.3389/fnmol.2025.1163636

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