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Article

Muscarinic acetylcholine receptor 3 is dominant in myopia progression.

Investigative ophthalmology & visual science - 21 Sept 2012

Lin Hui-Ju, Wan Lei, Chen Wen-Chi, Lin Jane-Ming, Lin Chao-Jen, Tsai Fuu-Jen

Abstract excerpt

PURPOSE: Numerous studies have proven that the nonselective muscarinic acetylcholine receptor (mAChR) antagonist atropine prevents the axial elongation that leads to myopia. Five distinct receptor genes (CHRM1-CHRM5), each encoding a muscarinic receptor protein (M[1]-M[5]), have been cloned. Copy number variations (CNVs), which constitute a substantial portion of genetic variability and structural genetic...

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Source

Identifiers

PMID: 22899762
DOI: 10.1167/iovs.11-9031

Genes

CHRM3
CHRM1
CHRM2
CHRM4
CHRM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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