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Clinical and genetic risk factors underlying severe consequence identified in 75 families with unilateral high myopia.

Journal of translational medicine - 19 Jan 2024

Jiang Yi, Xiao Xueshan, Sun Wenmin, Wang Yingwei, Li Shiqiang, Jia Xiaoyun, Wang Panfeng, Hejtmancik J Fielding, Zhang Qingjiong

Abstract excerpt

BACKGROUNDS: Unilateral high myopia (uHM), commonly observed in patients with retinal diseases or only with high myopia, is frequently associated with amblyopia with poor prognosis. This study aims to reveal the clinical and genetic spectrum of uHM in a large Chinese cohort. METHODS: A total of 75 probands with simplex uHM were included in our Pediatric and Genetic Eye Clinic. Patients with significant posterior...

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PMID: 38243264
DOI: 10.1186/s12967-024-04886-5
PMCID: PMC10797748

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