Article
Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.
Methods (San Diego, Calif.) - 1 Dec 2012
Neveu Grégory, Cassonnet Patricia, Vidalain Pierre-Olivier, Rolloy Caroline, Mendoza José, Jones Louis, Tangy Frédéric, Muller Mandy, Demeret Caroline, Tafforeau Lionel, Lotteau Vincent, Rabourdin-Combe Chantal, Travé Gilles, Dricot Amélie, Hill David E, Vidal Marc, Favre Michel, Jacob Yves
Abstract excerpt
Comparative interactomics is a strategy for inferring potential interactions among orthologous proteins or "interologs". Herein we focus, in contrast to standard homology-based inference, on the divergence of protein interaction profiles among closely related organisms, showing that the approach can correlate specific traits to phenotypic differences. As a model, this new comparative interactomic approach was...
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