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Article

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.

Neurology - 10 Nov 2009

Yu J, Deshmukh H, Gutmann R J, Emnett R J, Rodriguez F J, Watson M A, Nagarajan R, Gutmann D H

Abstract excerpt

OBJECTIVE: Independent studies have previously demonstrated that both the HIPK2 and BRAF genes are amplified and rearranged, respectively, in pilocytic astrocytomas (PAs). The purpose of this study was to further investigate the frequency of BRAF and HIPK2 alterations in PAs, the concordance of these events, and their relationship to clinical phenotype. METHODS: We performed extensive characterization by...

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Share to Astrocytoma
Share to Carrier Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Amplification

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Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 19794125
DOI: 10.1212/WNL.0b013e3181c0664a
PMCID: PMC2777068

Genes

BRAF
HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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