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Article

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for <i>Helicobacter pylori</i>

14 Aug 2012

Abstract excerpt

Campylobacter and Helicobacter species express a 6-amino-6-deoxyfutalosine N-ribosylhydrolase (HpMTAN) proposed to function in menaquinone synthesis. BuT-DADMe-ImmA is a 36 pM transition state analogue of HpMTAN, and the crystal structure of the enzyme-inhibitor complex reveals the mechanism of inhibition. BuT-DADMe-ImmA has a MIC(90) value of <8 ng/mL for Helicobacter pylori growth but does not cause growth...

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PMID: 22891633
DOI: 10.1021/bi3009664

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