Article
The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996
Fonné-Pfister R, Chemla P, Ward E, Girardet M, Kreuz K E, Honzatko R B, Fromm H J, Schär H P, Grütter M G, Cowan-Jacob S W
Abstract excerpt
(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate to the target enzyme was analyzed by determining the crystal structure of the enzyme-inhibitor complex...
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