Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional investigations of Ureaplasma parvum UMP kinase--a potential antibacterial drug target.

The FEBS journal - 1 Dec 2007

Egeblad-Welin Louise, Welin Martin, Wang Liya, Eriksson Staffan

Abstract excerpt

The crystal structure of uridine monophosphate kinase (UMP kinase, UMPK) from the opportunistic pathogen Ureaplasma parvum was determined and showed similar three-dimensional fold as other bacterial and archaeal UMPKs that all belong to the amino acid kinase family. Recombinant UpUMPK exhibited Michaelis-Menten kinetics with UMP, with K(m) and V(max) values of 214 +/- 4 microm and 262 +/- 24...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Anti-Bacterial Agents
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetics

Share to Recombinant Proteins

Share to Structure-Activity Relationship

Share to Substrate Specificity

Share to Uridine Monophosphate

Source

Identifiers

PMID: 18021254
DOI: 10.1111/j.1742-4658.2007.06157.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional investigations of Ureaplasma parvum UMP kinase--a potential antibacterial drug target.PMID 18021254Read ↗

Structure-function relationships of UMP kinases from pyrH mutants of Gram-negative bacteria.Semantic proximity Read ↗

Human UMP-CMP Kinase 2, a Novel Nucleoside Monophosphate Kinase Localized in MitochondriaSemantic proximity Read ↗

Thymidylate Kinase: An Old Topic Brings New PerspectivesSemantic proximity Read ↗

The site for the allosteric activator GTP of Escherichia coli UMP kinase.Semantic proximity Read ↗

Structural basis for the reaction mechanism of UDP-glucose pyrophosphorylase.Semantic proximity Read ↗

Structural and Biochemical Studies on the Reaction Mechanism of Uridine-Cytidine Kinase.Semantic proximity Read ↗

Mutational analysis of the uracil DNA glycosylase inhibitor protein and its interaction with Escherichia coli uracil DNA glycosylase.Semantic proximity Read ↗

Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States.Semantic proximity Read ↗

Structures of Burkholderia thailandensis nucleoside kinase: implications for the catalytic mechanism and nucleoside selectivity.Semantic proximity Read ↗

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.Semantic proximity Read ↗

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.Semantic proximity Read ↗

A functional analysis of the allosteric nucleotide monophosphate binding site of carbamoyl phosphate synthetase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.