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In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacteriumHelicobacter pylori

1 Jan 2018

Abstract excerpt

Adenylosuccinate synthetase (AdSS) is an enzyme at regulatory point of purine metabolism. In pathogenic organisms which utilise only the purine salvage pathway, AdSS asserts itself as a promising drug target. One of these organisms is Helicobacter pylori, a wide-spread human pathogen involved in the development of many diseases. The rate of H. pylori antibiotic resistance is on the increase, making the quest for...

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PMID: 30191734
DOI: 10.1080/14756366.2018.1506773

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