Article
The PxDLLCxE sequence in conserved region 2 of human papilloma virus 18 protein E7 is required for E7 binding to centromere protein C.
Oncology - 1 Jan 2012
Yaginuma Yuji, Eguchi Ayami, Yoshimoto Masafumi, Ogawa Katsuhiro
Abstract excerpt
High-risk human papillomaviruses (HPVs) are etiologically linked to human cervical and oral cancers. HPV infection leads to aneuploidy, a numerical chromosomal aberration caused by dysregulation of chromosomal segregation. We found that high-risk HPV18 and HPV58 E7 proteins bind to centromere pro...
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