Article
Runs of homozygosity and population history in cattle.
BMC genetics - 14 Aug 2012
Purfield Deirdre C, Berry Donagh P, McParland Sinead, Bradley Daniel G
Abstract excerpt
BACKGROUND: Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. The extent and frequency of ROHs may inform on the ancestry of an individual and its population. Here we use high density (n = 777,962) bi-allelic SNPs in a range of cattle breed samples to correlate ROH with the pedigree-based...
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