Article
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2011
Park Laibaik, Wang Gang, Zhou Ping, Zhou Joan, Pitstick Rose, Previti Mary Lou, Younkin Linda, Younkin Steven G, Van Nostrand William E, Cho Sunghee, Anrather Josef, Carlson George A, Iadecola Costantino
Abstract excerpt
Increasing evidence indicates that cerebrovascular dysfunction plays a pathogenic role in Alzheimer's dementia (AD). Amyloid-β (Aβ), a peptide central to the pathogenesis of AD, has profound vascular effects mediated, for the most part, by reactive oxygen species produced by the enzyme NADPH oxidase. The mechanisms linking Aβ to NADPH oxidase-dependent vascular oxidative stress have not been identified, however....
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