Article
Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model.
Journal of psychiatric research - 1 Oct 2012
Filiou Michaela D, Teplytska Larysa, Otte David M, Zimmer Andreas, Turck Christoph W
Abstract excerpt
G72/G30 is a primate-specific locus that has been repeatedly implicated as a risk factor in genetic studies of schizophrenia. The function of the longest G72 splice variant (LG72 protein) encoded by this locus is not fully understood. To investigate the role of the LG72 protein in vivo, we have generated transgenic (G72Tg) mice carrying the G72/G30 locus that exhibit schizophrenia-like symptoms. We investigated...
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