Article
Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function.
Molecular psychiatry - 1 Jul 2008
Kvajo M, Dhilla A, Swor D E, Karayiorgou M, Gogos J A
Abstract excerpt
G72 is a strong candidate susceptibility gene for schizophrenia and bipolar disorder, whose function remains enigmatic. Here we show that one splicing isoform of the gene (LG72) encodes for a mitochondrial protein. We also provide convergent lines of evidence that increase of endogenous or exogenous G72 levels promotes robust mitochondrial fragmentation in mammalian cell lines and primary neurons, which proceeds...
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