Article
Investigation of G72 (DAOA) expression in the human brain.
BMC psychiatry - 11 Dec 2008
Benzel Isabel, Kew James N C, Viknaraja Ramya, Kelly Fiona, de Belleroche Jacqueline, Hirsch Steven, Sanderson Thirza H, Maycox Peter R
Abstract excerpt
BACKGROUND: Polymorphisms at the G72/G30 locus on chromosome 13q have been associated with schizophrenia or bipolar disorder in more than ten independent studies. Even though the genetic findings are very robust, the physiological role of the predicted G72 protein has thus far not been resolved. Initial reports suggested G72 as an activator of D-amino acid oxidase (DAO), supporting the glutamate dysfunction...
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