Article
Identification of four gene variants associated with myocardial infarction.
American journal of human genetics - 1 Oct 2005
Shiffman Dov, Ellis Stephen G, Rowland Charles M, Malloy Mary J, Luke May M, Iakoubova Olga A, Pullinger Clive R, Cassano June, Aouizerat Bradley E, Fenwick Raymond G, Reitz Richard E, Catanese Joseph J, Leong Diane U, Zellner Christian, Sninsky John J, Topol Eric J, Devlin James J, Kane John P
Abstract excerpt
Family history is a major risk factor for myocardial infarction (MI). However, known gene variants associated with MI cannot fully explain the genetic component of MI risk. We hypothesized that a gene-centric association study that was not limited to candidate genes could identify novel genetic associations with MI. We studied 11,053 single-nucleotide polymorphisms (SNPs) in 6,891 genes, focusing on SNPs that...
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