Article
Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach.
Journal of molecular medicine (Berlin, Germany) - 1 Nov 2007
Barbaux Sandrine, Tregouet David-Alexandre, Nicaud Viviane, Poirier Odette, Perret Claire, Godefroy Tiphaine, Francomme Carole, Combadiere Christophe, Arveiler Dominique, Luc Gerald, Ruidavets Jean-Bernard, Evans Alun E, Kee Frank, Morrison Caroline, Tiret Laurence, Brand-Herrmann Stefan Martin, Cambien François
Abstract excerpt
The hypothesis of a causal link between inflammation and atherosclerosis would be strengthened if variants of inflammatory genes were associated with disease. Polymorphisms of 33 genes encoding inflammatory molecules were tested for association with myocardial infarction (MI). Patients with MI and a parental history of MI (n = 312) and controls from the UK (n = 317) were genotyped for 162 polymorphisms. Thirteen...
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