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Article

Mechanisms and frequency of resistance to temafloxacin.

The American journal of medicine - 30 Dec 1991

Appelbaum P C

Abstract excerpt

The bactericidal activity of temafloxacin and other fluoroquinolones is attributed to inhibition of bacterial DNA gyrase (topoisomerase II), an enzyme that regulates supercoiling and uncoiling of DNA. Because of this unique bactericidal mechanism of action, resistance to fluoroquinolones is limited to spontaneous mutations. In vitro studies were conducted to determine the frequency at which spontaneous resistance...

Topics

Anti-Infective Agents
Bacteria
Drug Resistance, Microbial
Escherichia coli
Fluoroquinolones
Methicillin Resistance
Mutation
Pseudomonas aeruginosa
Quinolones
Staphylococcus aureus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1662892
DOI: 10.1016/0002-9343(91)90306-i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1662892-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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