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Article

Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling.

Cell death & disease - 9 Aug 2012

Queudeville M, Seyfried F, Eckhoff S M, Trentin L, Ulrich S, Schirmer M, Debatin K-M, Meyer L H

Abstract excerpt

Previously, we found that rapid leukemia engraftment (short time to leukemia, TTL(short)) in the NOD/SCID/huALL (non-obese diabetic/severe combined immuno-deficiency/human acute lymphoblastic leukemia) xenograft model is indicative of early patient relapse. As earlier intact apoptosis sensitivity was predictive for good prognosis in patients, we investigated the importance of apoptosis signaling on NOD/SCID/huALL...

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Identifiers

PMID: 22875001
DOI: 10.1038/cddis.2012.107
PMCID: PMC3434672

Genes

TTL
DAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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