Article
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
1 Aug 2011
Abstract excerpt
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer of immature T cells that often shows aberrant activation of Notch1 and PI3K-Akt pathways. Although mutations that activate PI3K-Akt signaling have previously been identified, the relative contribution of growth factor-dependent activation is unclear. We show here that pharmacologic inhibition or genetic deletion of insulin-like growth factor 1...
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