Article
Minor clone provides a reservoir for relapse in multiple myeloma.
Leukemia - 1 Feb 2013
Magrangeas F, Avet-Loiseau H, Gouraud W, Lodé L, Decaux O, Godmer P, Garderet L, Voillat L, Facon T, Stoppa A M, Marit G, Hulin C, Casassus P, Tiab M, Voog E, Randriamalala E, Anderson K C, Moreau P, Munshi N C, Minvielle S
Abstract excerpt
Recent studies have provided direct evidence for genetic variegation in subclones for various cancer types. However, little is known about subclonal evolutionary processes according to treatment and subsequent relapse in multiple myeloma (MM). This issue was addressed in a cohort of 24 MM patients treated either with conventional chemotherapy or with the proteasome inhibitor, bortezomib. As MM is a highly...
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