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Article

A comparative study of cold- and warm-adapted Endonucleases A using sequence analyses and molecular dynamics simulations.

PloS one - 1 Jan 2017

Michetti Davide, Brandsdal Bjørn Olav, Bon Davide, Isaksen Geir Villy, Tiberti Matteo, Papaleo Elena

Abstract excerpt

The psychrophilic and mesophilic endonucleases A (EndA) from Aliivibrio salmonicida (VsEndA) and Vibrio cholera (VcEndA) have been studied experimentally in terms of the biophysical properties related to thermal adaptation. The analyses of their static X-ray structures was no sufficient to rationalize the determinants of their adaptive traits at the molecular level. Thus, we used Molecular Dynamics (MD)...

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Identifiers

PMID: 28192428
DOI: 10.1371/journal.pone.0169586
PMCID: PMC5305256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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