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Article

Lack of response to unaligned chromosomes in mammalian female gametes

15 Aug 2012

Abstract excerpt

Chromosome segregation errors are highly frequent in mammalian female meiosis, and their incidence gradually increases with maternal age. The fate of aneuploid eggs is obviously dependent on the stringency of mechanisms for detecting unattached or repairing incorrectly attached kinetochores. In case of their failure, the newly formed embryo will inherit the impaired set of chromosomes, which will have severe...

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PMID: 22871737
DOI: 10.4161/cc.21398

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